Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.73 |
| ▸ | RAB9A | P51151 | 2/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | MAPT | P10636 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | CHEK2 | O96017 | 7/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | APEX1 | P27695 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.51 |
| ▸ | F10 | P00742 | 1/20 | 0.51 |
| ▸ | F7 | P08709 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6374801 | 0.91 | HDAC6 (0.62) | HDAC6RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL7050481 | 0.90 | HDAC6 (0.59) | HDAC6RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL18229598 | 0.85 | HDAC6 (1.00) | HDAC6RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL6374805 | 0.81 | HDAC6 (0.51) | HDAC6RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL14347041 | 0.79 | CHEK2 (0.60) | CHEK2APEX1NPSR1F2F10 | |
| SCHEMBL6368278 | 0.78 | KDM4E (0.52) | HDAC6ALDH1A1CHEK2APEX1NPSR1 | |
| SCHEMBL4657967 | 0.77 | HDAC6 (0.60) | HDAC6RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL20085778 | 0.77 | GAA (0.68) | HDAC6ALDH1A1MAPTSMN1; SMN2HDAC1 | |
| SCHEMBL6367630 | 0.77 | HDAC6 (0.59) | HDAC6RAB9AALDH1A1MAPTSMN1; SMN2 | |
| SCHEMBL8974004 | 0.76 | KMT2A (0.77) | HDAC6RAB9AALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003024451-A1 | 2-(2-PHENYLETHYL)-BENZIMIDAZOLE-5-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-03-27 | — | — | WO | disclosed |