Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.48 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.46 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6374805 | 0.91 | HDAC6 (0.51) | HDAC6RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL7050488 | 0.90 | HDAC6 (0.73) | HDAC6RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL9598107 | 0.83 | APEX1 (0.45) | MAPTCHRM1CHEK2KDM4E | |
| SCHEMBL9569971 | 0.83 | APEX1 (0.45) | MAPTALDH1A1CHRM1CHEK2KDM4E | |
| SCHEMBL9028459 | 0.82 | F10 (0.55) | CHEK2 | |
| SCHEMBL6374801 | 0.81 | HDAC6 (0.62) | HDAC6RAB9AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11887806 | 0.80 | APEX1 (0.64) | HDAC6RAB9ANPC1ALDH1A1CHRM1 | |
| SCHEMBL22533832 | 0.79 | MMP2 (0.50) | RAB9ANPC1GAAHTTCHEK2 | |
| SCHEMBL3764806 | 0.79 | MAPT (0.78) | HDAC6RAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL6368287 | 0.78 | PKM (0.44) | MAPTGAALMNAHTTCHEK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003024451-A1 | 2-(2-PHENYLETHYL)-BENZIMIDAZOLE-5-CARBOXAMIDE DERIVATIVES AND THEIR USE AS TRYPTASE INHIBITORS | BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) | 2003-03-27 | — | — | WO | disclosed |