SCHEMBL7051552

SCHEMBL7051552

O=C1Nc2cc(Cl)c(Cl)cc2C(=O)C1=NOC(=O)c1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES1 P23141 1/20 0.47
KMT2A Q03164 5/20 0.43
ALDH1A1 P00352 5/20 0.43
HPGD P15428 4/20 0.43
F2 P00734 1/20 0.43
ATM Q13315 1/20 0.43
MEN1 O00255 1/20 0.40
MAPK1 P28482 1/20 0.40
CYP2C9 P11712 1/20 0.37
GAA P10253 2/20 0.36
MAPT P10636 4/20 0.36
L3MBTL1 Q9Y468 2/20 0.36
HCRTR1 O43613 1/20 0.36
HSP90AA1 P07900 2/20 0.36
GFER P55789 1/20 0.36
LRRK2 Q5S007 1/20 0.35
PLA2G1B P04054 1/20 0.35
ATG4B Q9Y4P1 1/20 0.35
LMNA P02545 1/20 0.35
TGM2 P21980 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7054835 0.90 CES1 (0.47) CES1KMT2AALDH1A1HPGDF2
SCHEMBL7050457 0.88 KMT2A (0.38) CES1KMT2AALDH1A1HPGDF2
SCHEMBL7049532 0.85 KMT2A (0.43) CES1KMT2AALDH1A1HPGDF2
SCHEMBL7051654 0.83 KMT2A (0.39) CES1KMT2AALDH1A1HPGDF2
SCHEMBL7052934 0.83 KMT2A (0.41) CES1KMT2AALDH1A1HPGDF2
SCHEMBL7052957 0.83 KMT2A (0.50) KMT2AALDH1A1HPGDF2ATM
SCHEMBL7051548 0.82 CES1 (0.48) CES1KMT2AALDH1A1HPGDF2
SCHEMBL7054757 0.81 CES1 (0.53) CES1KMT2AALDH1A1MEN1MAPT
SCHEMBL7054941 0.80 KMT2A (0.38) CES1KMT2AALDH1A1HPGDF2
SCHEMBL7054176 0.79 KMT2A (0.38) CES1KMT2AALDH1A1HPGDF2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0706396-B1 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE OREGON STATE (US) 2003-05-02 EP disclosed
US-5652368-A NERVOUS SYSTEM DISORDERS, ALZHEIMER'S DISEASE THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-07-29 US disclosed
US-5475007-A Preventing convulsions THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1995-12-12 US disclosed