Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 20/20 | 0.56 |
| ▸ | MTNR1B | P49286 | 19/20 | 0.56 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
| ▸ | NQO2 | P16083 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.37 |
| ▸ | MPO | P05164 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8822745 | 0.82 | MTNR1A (0.40) | MTNR1AMTNR1BHTR2CNQO2 | |
| SCHEMBL7057865 | 0.80 | MTNR1A (0.47) | MTNR1AMTNR1BHTR2CNQO2KDM4E | |
| SCHEMBL7055536 | 0.79 | MTNR1A (0.48) | MTNR1AMTNR1BHTR2CNQO2KDM4E | |
| SCHEMBL7051523 | 0.76 | MTNR1A (0.62) | MTNR1AMTNR1BHTR2C | |
| SCHEMBL8822754 | 0.73 | MTNR1A (0.37) | MTNR1AMTNR1B | |
| SCHEMBL1310442 | 0.72 | MTNR1A (1.00) | MTNR1AMTNR1BNQO2KDM4EMEN1 | |
| SCHEMBL8822781 | 0.72 | MTNR1A (0.41) | MTNR1AMTNR1BHTR2CNQO2KDM4E | |
| SCHEMBL7055786 | 0.72 | MTNR1A (0.75) | MTNR1AMTNR1BHTR2CNQO2KDM4E | |
| SCHEMBL7055803 | 0.72 | MTNR1A (0.65) | MTNR1AMTNR1BHTR2CNQO2KDM4E | |
| SCHEMBL7055900 | 0.72 | MTNR1A (0.65) | MTNR1AMTNR1BHTR2CNQO2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656209-B1 | Melatonin derivatives for use in treating desynchronization disorders | LILLY CO ELI (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-0655243-B1 | Melatonin derivatives for use in treating sleep disorders | LILLY CO ELI (US) | 2002-08-21 | — | — | EP | disclosed |
| US-6180657-B1 | SLEEP DISORDERS | ELI LILLY AND COMPANY | 2001-01-30 | — | — | US | disclosed |
| US-5654325-A | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0748627-A2 | Melatonin agonists for use in the treatment of benign prostatic hyperplasia | ELI LILLY AND COMPANY (US) | 1996-12-18 | — | — | EP | disclosed |
| EP-0656209-A2 | Melatonin derivatives for use in treating desynchronization disorders | ELI LILLY AND COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |
| EP-0655243-A2 | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |
| US-4997845-A | β-alkylmelatonins as ovulation inhibitors | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |