Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2B | P41595 | 2/20 | 0.59 |
| ▸ | MTNR1A | P48039 | 10/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 9/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | APEX1 | P27695 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | THPO | P40225 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8822758 | 0.95 | MTNR1A (0.66) | HTR2BMTNR1AMTNR1BCYP1A2CYP3A4 | |
| SCHEMBL7060010 | 0.90 | MTNR1A (0.50) | HTR2BMTNR1AMTNR1BHTR1A | |
| SCHEMBL4967386 | 0.87 | MTNR1A (0.76) | HTR2BMTNR1AMTNR1BCYP1A2CYP3A4 | |
| SCHEMBL4963214 | 0.86 | MTNR1A (0.76) | HTR2BMTNR1AMTNR1BCYP1A2CYP3A4 | |
| SCHEMBL18222529 | 0.86 | MTNR1A (0.76) | HTR2BMTNR1AMTNR1BCYP1A2CYP3A4 | |
| SCHEMBL7058953 | 0.84 | MTNR1A (0.60) | HTR2BMTNR1AMTNR1BCYP1A2CYP3A4 | |
| SCHEMBL7055786 | 0.80 | MTNR1A (0.75) | HTR2BMTNR1AMTNR1BCYP1A2CYP3A4 | |
| SCHEMBL8822703 | 0.79 | MTNR1A (0.47) | HTR2BMTNR1AMTNR1BHTR1A | |
| SCHEMBL7050446 | 0.78 | MTNR1A (0.52) | HTR2BMTNR1AMTNR1BCYP1A2CYP3A4 | |
| SCHEMBL13390756 | 0.75 | MTNR1A (0.76) | HTR2BMTNR1AMTNR1BCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656209-B1 | Melatonin derivatives for use in treating desynchronization disorders | LILLY CO ELI (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-0655243-B1 | Melatonin derivatives for use in treating sleep disorders | LILLY CO ELI (US) | 2002-08-21 | — | — | EP | disclosed |
| US-6180657-B1 | SLEEP DISORDERS | ELI LILLY AND COMPANY | 2001-01-30 | — | — | US | disclosed |
| US-5654325-A | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| EP-0748627-A2 | Melatonin agonists for use in the treatment of benign prostatic hyperplasia | ELI LILLY AND COMPANY (US) | 1996-12-18 | — | — | EP | disclosed |
| EP-0656209-A2 | Melatonin derivatives for use in treating desynchronization disorders | ELI LILLY AND COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |
| EP-0655243-A2 | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |
| US-4997845-A | β-alkylmelatonins as ovulation inhibitors | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |