Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 7/20 | 0.50 |
| ▸ | P2RY12 | Q9H244 | 5/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048623 | 0.89 | HTT (0.67) | HTTTSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL7053533 | 0.88 | HTT (0.56) | HTTTSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL7046754 | 0.84 | ALDH1A1 (0.48) | HTTTSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL7051646 | 0.81 | HRH4 (0.58) | HTTTSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL7047529 | 0.80 | HRH4 (0.57) | HTTTSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL7050933 | 0.79 | KDM4E (0.43) | HTTTSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL7052745 | 0.77 | MEN1 (0.66) | HTTTSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL5849808 | 0.76 | P2RY12 (0.80) | HTTTSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL7054382 | 0.76 | SMN1; SMN2 (0.51) | HTTTSHRSMN1; SMN2MAPTTP53 | |
| SCHEMBL7048493 | 0.76 | SMN1; SMN2 (0.51) | HTTTSHRSMN1; SMN2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003022214-A2 | PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2003-03-20 | — | — | WO | disclosed |