Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.81 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.81 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.81 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.81 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | ATM | Q13315 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | ELANE | P08246 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053073 | 0.90 | PDE4A (0.82) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7051831 | 0.90 | PDE4A (1.00) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7053635 | 0.88 | PDE4A (0.68) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7054219 | 0.88 | PDE4A (0.89) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7051848 | 0.86 | PDE4A (0.67) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7058531 | 0.85 | ALDH1A1 (0.66) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| Hydrochloric Acid SCHEMBL7055242 | 0.84 | ALDH1A1 (0.65) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7051841 | 0.81 | PDE4A (0.80) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7051840 | 0.81 | PDE4A (0.76) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7056993 | 0.80 | PDE4A (0.78) | PDE4APDE4BPDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0841929-B1 | QUINOLONES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-07 | — | — | EP | claimed |
| EP-0841929-B1 | QUINOLONES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-07 | — | — | EP | disclosed |
| US-5891878-A | Quinolones and their therapeutic use | CHIROSCIENCE LIMITED (GB) | 1999-04-06 | — | — | US | disclosed |
| EP-0841929-A1 | QUINOLONES AND THEIR THERAPEUTIC USE | Chiroscience Limited (GB) | 1998-05-20 | — | — | EP | disclosed |
| WO-1997004779-A1 | QUINOLONES AND THEIR THERAPEUTIC USE | CHIROSCIENCE LIMITED (GB) | 1997-02-13 | — | — | WO | disclosed |