Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLRA3 | O75311 | 1/20 | 0.47 |
| ▸ | GLRB | P48167 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CA2 | P00918 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | TYR | P14679 | 1/20 | 0.40 |
| ▸ | HSPA5 | P11021 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27852409 | 0.84 | GLRA3 (0.47) | GLRA3GLRBCYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL28648461 | 0.81 | GLRA3 (0.55) | GLRA3GLRBCYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL28661953 | 0.80 | HMGB1 (0.41) | CYP2C9ALDH1A1POLBKMT2ATDP1 | |
| SCHEMBL7050926 | 0.80 | HMGB1 (0.49) | CYP2C9ALDH1A1CYP3A4KMT2ATDP1 | |
| SCHEMBL10000643 | 0.78 | CYP2C19 (0.52) | GLRA3GLRBCYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL28622237 | 0.77 | GLRA3 (0.36) | GLRA3GLRBCYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL10884556 | 0.75 | GLRA3 (0.45) | GLRA3GLRBCYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL15005537 | 0.75 | ALOX15 (0.48) | GLRA3GLRBCYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL5000262 | 0.75 | GLRA3 (0.52) | GLRA3GLRBCYP2C19SMN1; SMN2CYP2C9 | |
| SCHEMBL30893094 | 0.75 | GLRA3 (0.52) | GLRA3GLRBCYP2C19SMN1; SMN2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0791590-B1 | Benzothiophenes, and formulations and methods using same | LILLY CO ELI (US) | 2003-05-02 | — | — | EP | disclosed |
| US-6432982-B1 | TREATING POST-MENOPAUSAL WOMEN HAVING OSTEOPOROSIS, CARDIOVASCULAR DISORDERS AND ESTROGEN-DEPENDENT CANCER; RESTENOSIS INHIBITION; ENDOMETRIOSIS | ELI LILLY AND COMPANY | 2002-08-13 | — | — | US | disclosed |
| WO-1997030985-A1 | BENZOTHIOPHENES, AND FORMULATIONS AND METHODS, USING SAME | ELI LILLY AND COMPANY (US) | 1997-08-28 | — | — | WO | disclosed |
| EP-0791590-A1 | Benzothiophenes, and formulations and methods using same | ELI LILLY AND COMPANY (US) | 1997-08-27 | — | — | EP | disclosed |