Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | GRIN2D | O15399 | 4/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 4/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 4/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.39 |
| ▸ | GRIN2C | Q14957 | 4/20 | 0.39 |
| ▸ | GRIN3A | Q8TCU5 | 4/20 | 0.39 |
| ▸ | CES1 | P23141 | 4/20 | 0.35 |
| ▸ | DNMT1 | P26358 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | GLP1R | P43220 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052184 | 1.00 | TSHR (0.42) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7048389 | 0.90 | TSHR (0.42) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7048387 | 0.90 | TSHR (0.42) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8872178 | 0.84 | TSHR (0.52) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7054965 | 0.82 | TSHR (0.36) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7052629 | 0.82 | CES1 (0.41) | CES1DNMT1SIRT2 | |
| SCHEMBL7052625 | 0.82 | CES1 (0.41) | CES1DNMT1SIRT2 | |
| SCHEMBL7050715 | 0.79 | TSHR (0.42) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7050717 | 0.79 | TSHR (0.42) | TSHRGRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL7053794 | 0.79 | ALDH1A1 (0.33) | ALDH1A1MAPTHSP90AA1CDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706396-B1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | OREGON STATE (US) | 2003-05-02 | — | — | EP | disclosed |
| US-5652368-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER'S DISEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-29 | — | — | US | disclosed |
| US-5475007-A | Preventing convulsions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-12 | — | — | US | disclosed |