SCHEMBL7052243

SCHEMBL7052243

COC(=O)C1=C(c2cccc(Cl)c2)CCN(C(=O)OC(C)(C)C)C1

nearest known ligand 0.58

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
SLC6A3 Q01959 8/20 0.58
SLC6A2 P23975 3/20 0.57
ESR2 Q92731 1/20 0.46
CHRM2 P08172 2/20 0.45
CHRM4 P08173 2/20 0.45
CHRM5 P08912 2/20 0.45
CHRM1 P11229 2/20 0.45
CHRM3 P20309 2/20 0.45
STS P08842 1/20 0.45
MKNK1 Q9BUB5 1/20 0.45
NR1H2 P55055 2/20 0.44
L3MBTL1 Q9Y468 1/20 0.43
SLC6A4 P31645 1/20 0.41
USP30 Q70CQ3 1/20 0.40
ALDH1A1 P00352 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7047941 0.89 SLC6A3 (0.47) SLC6A3SLC6A2ESR2STSMKNK1
SCHEMBL8261717 0.88 CHRM2 (0.51) SLC6A3SLC6A2ESR2CHRM2CHRM4
SCHEMBL8253723 0.88 ESR2 (0.52) SLC6A3SLC6A2ESR2CHRM2CHRM4
SCHEMBL10181943 0.87 CHRM2 (0.45) SLC6A3SLC6A2ESR2CHRM2CHRM4
SCHEMBL8263641 0.87 CHRM2 (0.45) SLC6A3SLC6A2ESR2CHRM2CHRM4
SCHEMBL3197517 0.87 SLC6A3 (0.54) SLC6A3SLC6A2ESR2CHRM2CHRM4
SCHEMBL6418231 0.87 CHRM5 (0.59) SLC6A3SLC6A2ESR2CHRM2CHRM4
SCHEMBL3194232 0.86 SLC6A3 (0.57) SLC6A3SLC6A2ESR2NR1H2SLC6A4
SCHEMBL8264380 0.85 ESR2 (0.49) SLC6A3SLC6A2ESR2CHRM2CHRM4
SCHEMBL8264951 0.85 SLC6A4 (0.62) SLC6A3SLC6A2ESR2CHRM2CHRM4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20030216441-A1 Farnesyltransferase inhibitors WEINSTOCK, STEVEN F. 2003-11-20 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030216441-A1 Farnesyltransferase inhibitors FNTA, FNTB, LCAT SLC6A3 4613/4885SLC6A2 4065/4885ESR2 1484/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.