Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARG | P13631 | 9/20 | 0.64 |
| ▸ | RARB | P10826 | 9/20 | 0.64 |
| ▸ | RARA | P10276 | 8/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.64 |
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | IKBKB | O14920 | 3/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321300 | 0.92 | RARA (0.64) | RARGRARBRARAKMT2AMEN1 | |
| SCHEMBL3807973 | 0.86 | RARB (0.67) | RARGRARBRARAKMT2AMEN1 | |
| SCHEMBL7786883 | 0.86 | RARB (0.46) | RARGRARBRARAKMT2AMEN1 | |
| SCHEMBL7047540 | 0.85 | RARB (0.50) | RARGRARBRARAKMT2AMEN1 | |
| SCHEMBL9286338 | 0.82 | SMN1; SMN2 (0.47) | RARGRARBRARAKMT2AMEN1 | |
| SCHEMBL7796793 | 0.82 | RARB (0.47) | RARGRARBRARAKMT2AMEN1 | |
| SCHEMBL7795164 | 0.81 | MEN1 (0.45) | RARGRARBRARAKMT2AMEN1 | |
| SCHEMBL12471355 | 0.79 | KDM4E (0.56) | KMT2AKDM4EALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7786885 | 0.79 | CHEK1 (0.50) | RARGRARBRARAKMT2AMEN1 | |
| O-Demethylated Adapalene SCHEMBL174205 | 0.79 | RARG (1.00) | RARGRARBRARAKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862910-B1 | Use of retinoids as skin pigmentation inducing agent | GALDERMA RECH DERMATOLOGIQUE (FR) | 2003-05-02 | — | — | EP | claimed |
| US-5942531-A | Phenolic/naphtholic retinoids for promoting skin/exoskeleton pigmentation | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 1999-08-24 | — | — | US | claimed |
| US-5942531-A | Phenolic/naphtholic retinoids for promoting skin/exoskeleton pigmentation | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (FR) | 1999-08-24 | — | — | US | disclosed |