Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.50 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.40 |
| ▸ | CA2 | P00918 | 1/20 | 0.40 |
| ▸ | CA3 | P07451 | 1/20 | 0.40 |
| ▸ | CA4 | P22748 | 1/20 | 0.40 |
| ▸ | CA6 | P23280 | 1/20 | 0.40 |
| ▸ | CA5A | P35218 | 1/20 | 0.40 |
| ▸ | CA7 | P43166 | 1/20 | 0.40 |
| ▸ | CA9 | Q16790 | 1/20 | 0.40 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.40 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7053234 | 1.00 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7053230 | 1.00 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7056726 | 0.86 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7054767 | 0.84 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7054773 | 0.84 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7054770 | 0.84 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7051399 | 0.81 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL309047 | 0.80 | PDE4A (0.60) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL6839328 | 0.78 | SMN1; SMN2 (0.62) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7055317 | 0.78 | MAPT (0.43) | PDE4APDE4BPDE4CPDE4DLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |
| US-5972936-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVER LIMITED (GB) | 1999-10-26 | — | — | US | disclosed |
| EP-0901482-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | Darwin Discovery Limited (GB) | 1999-03-17 | — | — | EP | disclosed |
| WO-1997044337-A1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LIMITED (GB) | 1997-11-27 | — | — | WO | disclosed |