Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 15/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7054767 | 1.00 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7054770 | 1.00 | PDE4A (0.46) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7049311 | 0.88 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7053234 | 0.84 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7053236 | 0.84 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7053230 | 0.84 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7055317 | 0.77 | MAPT (0.43) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7055316 | 0.77 | MAPT (0.43) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7055321 | 0.77 | MAPT (0.43) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL7368427 | 0.75 | PDE4D (0.42) | PDE4APDE4BPDE4CPDE4DMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |
| US-5972936-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVER LIMITED (GB) | 1999-10-26 | — | — | US | disclosed |