⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048361 | 0.92 | — | — | |
| SCHEMBL7050083 | 0.90 | CCNB2 (0.32) | — | |
| SCHEMBL7050911 | 0.89 | EPAS1 (0.34) | — | |
| SCHEMBL7054946 | 0.88 | — | — | |
| SCHEMBL7052292 | 0.87 | ALDH1A1 (0.31) | — | |
| SCHEMBL7052760 | 0.85 | MAPT (0.36) | — | |
| SCHEMBL7051891 | 0.84 | ALDH1A1 (0.32) | — | |
| SCHEMBL7051686 | 0.84 | — | — | |
| SCHEMBL7051689 | 0.84 | — | — | |
| SCHEMBL7053903 | 0.82 | CCNB2 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706396-B1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | OREGON STATE (US) | 2003-05-02 | — | — | EP | disclosed |
| EP-0706396-A4 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | OREGON STATE (US) | 1998-12-09 | — | — | EP | disclosed |
| US-5652368-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER'S DISEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-29 | — | — | US | disclosed |
| EP-0706396-A1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | STATE OF OREGON ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OF OREGON STATE UNIVERSITY (US) | 1996-04-17 | — | — | EP | disclosed |
| US-5475007-A | Preventing convulsions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-12 | — | — | US | disclosed |
| WO-1994027605-A1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION, ACTING FOR AND ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY AND THE UNIVERSITY OF OREGON, EUGENE, OREGON (US) | 1994-12-08 | — | — | WO | disclosed |