Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 6/20 | 0.73 |
| ▸ | IKBKB | O14920 | 3/20 | 0.73 |
| ▸ | JAK3 | P52333 | 1/20 | 0.73 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.66 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.65 |
| ▸ | KIF11 | P52732 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5898639 | 0.90 | JAK2 (0.65) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL4087748 | 0.90 | IKBKB (0.73) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL1385889 | 0.85 | JAK2 (1.00) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL3617795 | 0.85 | CHEK1 (0.65) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL7055474 | 0.84 | IKBKB (0.78) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL10051886 | 0.83 | JAK2 (0.89) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL1563085 | 0.81 | CHEK1 (0.53) | JAK2IKBKBJAK3MEN1KMT2A | |
| SCHEMBL1563080 | 0.81 | CHEK1 (0.79) | CHEK1 | |
| SCHEMBL717369 | 0.80 | IKBKB (1.00) | JAK2IKBKBJAK3MEN1EIF2AK2 | |
| SCHEMBL5898694 | 0.80 | JAK2 (0.62) | JAK2IKBKBJAK3MEN1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |