Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 12/20 | 0.65 |
| ▸ | IKBKB | O14920 | 3/20 | 0.59 |
| ▸ | JAK2 | O60674 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.56 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3607430 | 0.86 | CHEK1 (0.69) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL7053485 | 0.85 | JAK2 (0.73) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL3614116 | 0.84 | IKBKB (0.81) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL4087748 | 0.82 | IKBKB (0.73) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL3618364 | 0.82 | CHEK1 (0.84) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL3618376 | 0.80 | CHEK1 (0.66) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL3603463 | 0.80 | CHEK1 (0.66) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL3611288 | 0.80 | CHEK1 (0.70) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL3611495 | 0.79 | CHEK1 (0.76) | CHEK1IKBKBJAK2MEN1EIF2AK2 | |
| SCHEMBL3612027 | 0.79 | CHEK1 (1.00) | CHEK1IKBKBJAK2MEN1EIF2AK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100029754-A1 | THIOPHENE-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | ASTRAZENECA AB (SW) | 2010-02-04 | — | — | US | disclosed |
| US-7572826-B2 | Thiophene-carboxamide derivatives and their use as inhibitors of the enzyme IKK-2 | ASTRAZENECA AB (SE) | 2009-08-11 | — | — | US | disclosed |
| US-20060058522-A1 | Thiophene-carboxamide derivatives and their use as inhibitors of the enzyme ikk-2 | ASTRAZENECA AB (SE) | 2006-03-16 | — | — | US | disclosed |
| EP-1583755-A1 | THIOPHENE-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZIME IKK-2 | AstraZeneca AB (SE) | 2005-10-12 | — | — | EP | disclosed |
| WO-2004063186-A1 | THIOPHENE-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZIME IKK-2 | ASTRAZENECA AB (SE) | 2004-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060058522-A1 | Thiophene-carboxamide derivatives and their use as inhibitors of the enzyme ikk-2 | NFKBIA, RELA, IKBKE | CHEK1 487/4885IKBKB 5/4885JAK2 163/4885 |
| US-20100029754-A1 | THIOPHENE-CARBOXAMIDE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE ENZYME IKK-2 | NFKBIA, RELA, IKBKE | CHEK1 487/4885IKBKB 5/4885JAK2 163/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.