Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 1/20 | 0.74 |
| ▸ | THRB | P10828 | 17/20 | 0.48 |
| ▸ | THRA | P10827 | 16/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7251532 | 0.91 | NR3C1 (0.62) | NR3C1THRBTHRA | |
| SCHEMBL6732356 | 0.91 | NR3C1 (0.62) | NR3C1THRBTHRAPTGDR2 | |
| SCHEMBL7053942 | 0.90 | NR3C1 (0.70) | NR3C1THRBTHRA | |
| SCHEMBL7052325 | 0.89 | NR3C1 (0.84) | NR3C1THRBTHRAPTGDR2 | |
| SCHEMBL7054870 | 0.85 | NR3C1 (0.81) | NR3C1THRBTHRA | |
| SCHEMBL5632584 | 0.85 | NR3C1 (1.00) | NR3C1THRBTHRA | |
| SCHEMBL7251756 | 0.84 | NR3C1 (0.68) | NR3C1THRBTHRA | |
| SCHEMBL7253471 | 0.84 | NR3C1 (0.82) | NR3C1THRBTHRA | |
| SCHEMBL7054470 | 0.84 | NR3C1 (0.84) | NR3C1THRBTHRAPTGDR2 | |
| SCHEMBL7250323 | 0.83 | NR3C1 (0.61) | NR3C1THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1102739-B1 | GLUCOCORTICOID AND THYROID HORMONE RECEPTOR LIGANDS FOR THE TREATMENT OF METABOLIC DISORDERS | KAROBIO AB (SE) | 2003-04-23 | — | — | EP | claimed |
| US-6492424-B1 | Glucocorticoid and thyroid hormone receptor ligands for the treatment of metabolic disorders | KARO BIO AB (SE) | 2002-12-10 | — | — | US | claimed |