Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 18/20 | 0.68 |
| ▸ | DRD2 | P14416 | 16/20 | 0.68 |
| ▸ | HTR1A | P08908 | 4/20 | 0.68 |
| ▸ | HTR2A | P28223 | 1/20 | 0.68 |
| ▸ | HTR2C | P28335 | 1/20 | 0.68 |
| ▸ | DRD4 | P21917 | 9/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.63 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.63 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.63 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.63 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055010 | 0.87 | DRD2 (0.61) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7056494 | 0.87 | DRD2 (0.60) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7055031 | 0.85 | DRD2 (0.64) | DRD3DRD2DRD4ADRA1A | |
| SCHEMBL7054522 | 0.85 | DRD2 (0.53) | DRD3DRD2DRD4ADRA1ASLC6A4 | |
| SCHEMBL7056485 | 0.82 | DRD2 (0.64) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7057784 | 0.82 | DRD2 (0.48) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7049915 | 0.81 | DRD2 (0.51) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL29730963 | 0.81 | DRD3 (1.00) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7050986 | 0.81 | DRD3 (0.56) | DRD3DRD2HTR1AHTR2AHTR2C | |
| SCHEMBL7057771 | 0.79 | DRD2 (0.58) | DRD3DRD2HTR1AHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028728-A1 | 4-(4-SUBSTITUTED PIPERAZINYL-1YL)-BUTYLCARBOXAMIDES AS D3 DOPAMINE SUBTYPE SELECTIVE LIGANDS | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2003-04-10 | — | — | WO | disclosed |