Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.32 |
| ▸ | F10 | P00742 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7052513 | 0.86 | ALDH1A1 (0.40) | PDE4APDE4BPDE4CPDE4DTP53 | |
| SCHEMBL7052721 | 0.81 | PDE4D (0.43) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7052278 | 0.78 | PDE4D (0.52) | PDE4APDE4BPDE4CPDE4DL3MBTL1 | |
| Morpholine SCHEMBL7050559 | 0.77 | PDE4B (0.37) | PDE4APDE4BPDE4CPDE4DTGFBR1 | |
| SCHEMBL7052696 | 0.77 | PDE4D (0.44) | PDE4APDE4BPDE4CPDE4DALDH1A1 | |
| SCHEMBL7054654 | 0.73 | PDE4D (0.44) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7054167 | 0.73 | PDE4D (0.40) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8352300 | 0.73 | PDE4D (0.39) | PDE4APDE4BPDE4CPDE4DLMNA | |
| SCHEMBL8357732 | 0.73 | PDE4D (0.42) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7053281 | 0.71 | PDE4D (0.46) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901482-B1 | BENZOFURAN CARBOXAMIDES AND THEIR THERAPEUTIC USE | DARWIN DISCOVERY LTD (GB) | 2003-05-02 | — | — | EP | disclosed |
| US-5972936-A | Benzofuran carboxamides and their therapeutic use | DARWIN DISCOVER LIMITED (GB) | 1999-10-26 | — | — | US | disclosed |