Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | APLNR | P35414 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7060998 | 0.91 | CYP3A4 (0.63) | MEN1KMT2AHSD17B10CYP3A4CYP2D6 | |
| SCHEMBL6478857 | 0.85 | MEN1 (0.58) | MEN1KMT2AAPLNRHSD17B10CYP3A4 | |
| SCHEMBL8636638 | 0.84 | NPC1 (0.61) | MEN1KMT2AAPLNRHSD17B10CYP3A4 | |
| SCHEMBL30831943 | 0.81 | HSD17B10 (0.75) | MEN1KMT2AAPLNRHSD17B10ALDH1A1 | |
| SCHEMBL267732 | 0.81 | CYP3A4 (0.62) | MEN1KMT2AAPLNRHSD17B10CYP3A4 | |
| SCHEMBL1097902 | 0.81 | HSD17B10 (0.75) | MEN1KMT2AAPLNRHSD17B10ALDH1A1 | |
| SCHEMBL29392677 | 0.81 | CYP3A4 (0.62) | MEN1KMT2AAPLNRHSD17B10CYP3A4 | |
| SCHEMBL6849659 | 0.81 | L3MBTL1 (0.58) | MEN1KMT2AHSD17B10ALDH1A1SMN1; SMN2 | |
| SCHEMBL4687391 | 0.80 | KMT2A (0.59) | MEN1KMT2AAPLNRHSD17B10ALDH1A1 | |
| SCHEMBL3456256 | 0.80 | KMT2A (0.56) | MEN1KMT2AAPLNRHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6589980-B2 | A compound which is 2,6-dihydroxy-8-methoxy-10,11-dioxa-benzo(b)fluoren-5-one or a pharmaceutically acceptable salt for treating or inhibiting osteoporosis or inhibiting bone demineralization in a mammal in need thereof | WYETH | 2003-07-08 | — | — | US | disclosed |
| US-20030087955-A1 | Substituted 10,11-benzo[b]fluoren-10-ones as estrogenic agents | WYETH | 2003-05-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030087955-A1 | Substituted 10,11-benzo[b]fluoren-10-ones as estrogenic agents | ESR1, GPER1, ESR2 | MEN1 1594/4885KMT2A 747/4885APLNR 1481/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.