Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 2/20 | 0.32 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.31 |
| ▸ | AURKC | Q9UQB9 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.31 |
| ▸ | CDK1 | P06493 | 1/20 | 0.31 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.31 |
| ▸ | AHR | P35869 | 1/20 | 0.31 |
| ▸ | GSK3A | P49840 | 1/20 | 0.31 |
| ▸ | GSK3B | P49841 | 1/20 | 0.31 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.31 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.31 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.31 |
| ▸ | TGM2 | P21980 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7048384 | 0.91 | AURKB (0.31) | AGTR1AURKBAURKCAURKACCNB2 | |
| SCHEMBL7048274 | 0.87 | GSK3A (0.31) | AURKBAURKCAURKAGSK3AGSK3B | |
| SCHEMBL7054468 | 0.86 | CES1 (0.40) | CCNB2CDK1CCNB1GSK3AGSK3B | |
| SCHEMBL7048371 | 0.84 | KMT2A (0.36) | MEN1KMT2AALDH1A1MAPTHTT | |
| SCHEMBL7052365 | 0.81 | ALDH1A1 (0.32) | AGTR1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7052368 | 0.81 | ALDH1A1 (0.32) | AGTR1MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL7051913 | 0.79 | GALR3 (0.31) | TGM2 | |
| SCHEMBL7054407 | 0.78 | GSK3A (0.31) | AURKBAURKCAURKAGSK3AGSK3B | |
| SCHEMBL7053356 | 0.77 | CES1 (0.43) | ALDH1A1MAPTCCNB2CDK1CCNB1 | |
| SCHEMBL7055737 | 0.74 | CES1 (0.38) | CCNB2CDK1CCNB1GSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0706396-B1 | 1,2,3,4-TETRAHYDROQUINOLINE-2,3,4-TRIONE-3 OR 4-OXIMES AND USE | OREGON STATE (US) | 2003-05-02 | — | — | EP | disclosed |
| US-5652368-A | NERVOUS SYSTEM DISORDERS, ALZHEIMER'S DISEASE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1997-07-29 | — | — | US | disclosed |
| US-5475007-A | Preventing convulsions | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1995-12-12 | — | — | US | disclosed |