Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 3/20 | 0.78 |
| ▸ | JAK2 | O60674 | 2/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.78 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.78 |
| ▸ | CHEK1 | O14757 | 15/20 | 0.62 |
| ▸ | CDK2AP1 | O14519 | 2/20 | 0.61 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7057178 | 0.88 | CHEK1 (0.76) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL717369 | 0.87 | IKBKB (1.00) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3086954 | 0.86 | IKBKB (0.82) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL7051438 | 0.86 | CHEK1 (0.82) | IKBKBJAK2CHEK1CDK2AP1MAP4K4 | |
| SCHEMBL28374187 | 0.83 | IKBKB (0.76) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL3614116 | 0.79 | IKBKB (0.81) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL1563692 | 0.77 | CHEK1 (1.00) | CHEK1CDK2AP1 | |
| SCHEMBL4215417 | 0.77 | CHEK1 (0.70) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL5898645 | 0.77 | IKBKB (0.80) | IKBKBJAK2MEN1EIF2AK2KMT2A | |
| SCHEMBL7055239 | 0.77 | CHEK1 (1.00) | IKBKBJAK2CHEK1CDK2AP1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |