Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 12/20 | 0.55 |
| ▸ | SLC6A4 | P31645 | 10/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.50 |
| ▸ | NOS2 | P35228 | 6/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.44 |
| ▸ | DRD3 | P35462 | 2/20 | 0.44 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9983096 | 0.83 | SLC6A2 (0.44) | SLC6A2SLC6A4CYP2D6NOS2SLC6A3 | |
| SCHEMBL9293469 | 0.83 | SLC6A2 (0.44) | SLC6A2SLC6A4CYP2D6NOS2SLC6A3 | |
| SCHEMBL7052799 | 0.81 | SLC6A2 (0.56) | SLC6A2SLC6A4CYP2D6NOS2SLC6A3 | |
| SCHEMBL5397302 | 0.80 | SLC6A2 (0.58) | SLC6A2SLC6A4CYP2D6NOS2SLC6A3 | |
| SCHEMBL4624371 | 0.80 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6NOS2SLC6A3 | |
| SCHEMBL2212613 | 0.80 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6NOS2SLC6A3 | |
| SCHEMBL7055269 | 0.80 | SLC6A2 (0.58) | SLC6A2SLC6A4CYP2D6NOS2SLC6A3 | |
| SCHEMBL5306302 | 0.80 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6NOS2SLC6A3 | |
| SCHEMBL5445187 | 0.80 | SLC6A2 (0.55) | SLC6A2SLC6A4CYP2D6NOS2SLC6A3 | |
| SCHEMBL2633864 | 0.80 | SLC6A2 (0.68) | SLC6A2SLC6A4CYP2D6NOS2SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0831799-B1 | COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS | NPS PHARMA INC (US) | 2003-05-02 | — | — | EP | claimed |
| EP-0831799-B1 | COMPOUNDS ACTIVE AT A NOVEL SITE ON RECEPTOR-OPERATED CALCIUM CHANNELS USEFUL FOR TREATMENT OF NEUROLOGICAL DISORDERS | NPS PHARMA INC (US) | 2003-05-02 | — | — | EP | disclosed |