SCHEMBL7055997

SCHEMBL7055997

O=C(O)C1CC2CC(CP(=O)(O)O)CC[C@H]2CN1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 1.00
KMT2A Q03164 2/20 1.00
KDM4E B2RXH2 1/20 1.00
GRIA1 P42261 4/20 0.61
GRIA2 P42262 4/20 0.61
GRIA3 P42263 4/20 0.61
GRIA4 P48058 4/20 0.61
GRIN2D O15399 3/20 0.61
GRIN3B O60391 3/20 0.61
GRIN1 Q05586 3/20 0.61
GRIN2A Q12879 3/20 0.61
GRIN2B Q13224 3/20 0.61
GRIN2C Q14957 3/20 0.61
GRIN3A Q8TCU5 3/20 0.61
ALDH1A1 P00352 1/20 0.61
CYP1A2 P05177 1/20 0.61
THRB P10828 1/20 0.61
ALOX15 P16050 1/20 0.61
CYP2C19 P33261 1/20 0.61
GRIK1 P39086 5/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7945708 1.00 MEN1 (1.00) MEN1KMT2AKDM4EGRIA1GRIA2
SCHEMBL13431268 1.00 MEN1 (1.00) MEN1KMT2AKDM4EGRIA1GRIA2
SCHEMBL195083 1.00 MEN1 (1.00) MEN1KMT2AKDM4EGRIA1GRIA2
SCHEMBL6021490 1.00 MEN1 (1.00) MEN1KMT2AKDM4EGRIA1GRIA2
SCHEMBL9410041 1.00 MEN1 (1.00) MEN1KMT2AKDM4EGRIA1GRIA2
SCHEMBL2763546 1.00 MEN1 (1.00) MEN1KMT2AKDM4EGRIA1GRIA2
SCHEMBL16668991 1.00 MEN1 (1.00) MEN1KMT2AKDM4EGRIA1GRIA2
SCHEMBL20241728 1.00 MEN1 (1.00) MEN1KMT2AKDM4EGRIA1GRIA2
Methanesulfonamide SCHEMBL8296539 0.91 MEN1 (0.83) MEN1KMT2AKDM4EGRIA1GRIA2
SCHEMBL13431280 0.89 KDM4E (0.80) MEN1KMT2AKDM4EGRIA1GRIA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101247853-A Substituted indole compounds having NOS inhibitory activity NEURAXON INC (CA) 2008-08-20 CN claimed
WO-2004039371-A2 COMPOSITIONS OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS AND NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF NEUROPATHIC PAIN PHARMACIA CORPORATION (US) 2004-05-13 WO claimed
CN-101528283-A Apparatus and method for delivering therapeutic and/or other agents to the inner ear and to other tissues NEUROSYSTEC CORP (US) 2009-09-09 CN disclosed
CN-101247853-A Substituted indole compounds having NOS inhibitory activity NEURAXON INC (CA) 2008-08-20 CN disclosed
CN-101163481-A Improved gacyclidine formulations NEUROSYSTEC CORP (US) 2008-04-16 CN disclosed
WO-2004039371-A2 COMPOSITIONS OF CYCLOOXYGENASE-2 SELECTIVE INHIBITORS AND NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OR PREVENTION OF NEUROPATHIC PAIN PHARMACIA CORPORATION (US) 2004-05-13 WO disclosed
US-5461156-A Stereocontrolled synthesis of cis-bicyclic compounds ELI LILLY AND COMPANY (US) 1995-10-24 US disclosed
US-5338851-A Nervous system disorders ELI LILLY AND COMPANY (US) 1994-08-16 US disclosed