Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 2/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 1.00 |
| ▸ | GRIA1 | P42261 | 4/20 | 0.61 |
| ▸ | GRIA2 | P42262 | 4/20 | 0.61 |
| ▸ | GRIA3 | P42263 | 4/20 | 0.61 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.61 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.61 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.61 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.61 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.61 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.61 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.61 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | THRB | P10828 | 1/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.61 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13431268 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4EGRIA1GRIA2 | |
| SCHEMBL195083 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4EGRIA1GRIA2 | |
| SCHEMBL6021490 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4EGRIA1GRIA2 | |
| SCHEMBL9410041 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4EGRIA1GRIA2 | |
| SCHEMBL2763546 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4EGRIA1GRIA2 | |
| SCHEMBL16668991 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4EGRIA1GRIA2 | |
| SCHEMBL7055997 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4EGRIA1GRIA2 | |
| SCHEMBL20241728 | 1.00 | MEN1 (1.00) | MEN1KMT2AKDM4EGRIA1GRIA2 | |
| Methanesulfonamide SCHEMBL8296539 | 0.91 | MEN1 (0.83) | MEN1KMT2AKDM4EGRIA1GRIA2 | |
| SCHEMBL13431280 | 0.89 | KDM4E (0.80) | MEN1KMT2AKDM4EGRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150190411-A1 | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-07-09 | — | — | US | disclosed |
| US-20150190411-A1 | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2015-07-09 | — | — | US | disclosed |
| US-20100075926-A1 | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2010-03-25 | — | — | US | disclosed |
| WO-2010011318-A2 | ACTIVATIQN OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) | 2010-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100075926-A1 | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | GRIK5, HDAC11, GRIK1 | MEN1 3148/4885KMT2A 1179/4885KDM4E 826/4885 |
| US-20150190411-A1 | ACTIVATION OF HISTONE DEACETYLASE 1 (HDAC1) PROTECTS AGAINST DNA DAMAGE AND INCREASES NEURONAL SURVIVAL | GRIK5, HDAC11, GRIK1 | MEN1 3160/4885KMT2A 1184/4885KDM4E 833/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.