Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12489209 | 0.74 | ALDH1A1 (0.38) | ALDH1A1LMNAHTTTSHRMAPT | |
| SCHEMBL19784252 | 0.70 | — | — | |
| SCHEMBL2830540 | 0.67 | ALDH1A1 (0.37) | ALDH1A1LMNAHTTTSHRMAPT | |
| SCHEMBL18898921 | 0.66 | ALDH1A1 (0.34) | ALDH1A1LMNAHTTTSHRMAPT | |
| SCHEMBL14251019 | 0.66 | ALDH1A1 (0.36) | ALDH1A1LMNAHTTTSHRMAPT | |
| SCHEMBL1700018 | 0.66 | ALDH1A1 (0.36) | ALDH1A1LMNAHTTTSHRMAPT | |
| SCHEMBL432006 | 0.64 | MAPT (0.54) | ALDH1A1LMNAHTTTSHRMAPT | |
| SCHEMBL11123442 | 0.59 | — | — | |
| SCHEMBL1830788 | 0.59 | — | — | |
| SCHEMBL11617099 | 0.58 | MAPT (0.46) | ALDH1A1LMNAHTTTSHRMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003034997-A2 | MODULATORS OF PHOSPHOINOSITIDE 3-KINASE | ICONIX PHARMACEUTICALS, INC. (US) | 2003-05-01 | — | — | WO | disclosed |