SCHEMBL7056856

SCHEMBL7056856

Clc1cc(Cl)c(Cl)c(C2CO2)c1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
AHR P35869 6/20 0.38
TSHR P16473 2/20 0.38
HSD17B10 Q99714 2/20 0.38
HPGD P15428 1/20 0.38
MEN1 O00255 1/20 0.33
PLA2G1B P04054 1/20 0.33
POLB P06746 1/20 0.33
NR4A1 P22736 1/20 0.33
PTPN7 P35236 1/20 0.33
BLM P54132 1/20 0.33
KMT2A Q03164 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
ATG4B Q9Y4P1 1/20 0.33
HTR2A P28223 1/20 0.33
HTR2C P28335 1/20 0.33
HTR2B P41595 1/20 0.33
CYP3A4 P08684 2/20 0.32
RECQL P46063 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7054788 0.80 CYP3A4 (0.43) ALDH1A1AHRTSHRHSD17B10HPGD
SCHEMBL7053304 0.75 ALDH1A1 (0.39) ALDH1A1AHRTSHRHSD17B10HPGD
SCHEMBL4311675 0.74 HTR2A (0.49) ALDH1A1TSHRHSD17B10HTR2AHTR2C
SCHEMBL29439088 0.74 HTR2A (0.49) ALDH1A1TSHRHSD17B10HTR2AHTR2C
SCHEMBL4311498 0.74 HTR2A (0.49) ALDH1A1TSHRHSD17B10HTR2AHTR2C
SCHEMBL7049820 0.74 TP53 (0.42) ALDH1A1TSHRHSD17B10TDP1HTR2A
SCHEMBL1583058 0.74 HTR2A (0.49) ALDH1A1TSHRHSD17B10HTR2AHTR2C
SCHEMBL15565267 0.73 ALDH1A1 (0.50) ALDH1A1AHRTSHRHSD17B10HPGD
SCHEMBL7053925 0.70 CYP3A4 (0.41) ALDH1A1AHRTSHRHSD17B10HPGD
SCHEMBL7050638 0.70 TSHR (0.37) AHRTSHRHSD17B10HPGDHTR2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0611826-B1 Processes for production of optically active epoxides DAICEL CHEM (JP) 2003-05-02 EP disclosed
US-5672504-A TREATING MIXED EPOXIDE ENANTIOMORPHS WITH MICROORGANISMS TO INCREASE CONCENTRATION OF OPTICALLY PURE S-ENANTIOMORPHS DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1997-09-30 US disclosed
EP-0611826-A2 Processes for production of optically active epoxides DAICEL CHEMICAL INDUSTRIES, LTD. (JP) 1994-08-24 EP disclosed