Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.80 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.80 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.80 |
| ▸ | LMNA | P02545 | 1/20 | 0.80 |
| ▸ | HPGD | P15428 | 2/20 | 0.76 |
| ▸ | IKBKB | O14920 | 7/20 | 0.74 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | ATM | Q13315 | 1/20 | 0.70 |
| ▸ | TP53 | P04637 | 2/20 | 0.66 |
| ▸ | POLB | P06746 | 1/20 | 0.66 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1406017 | 0.90 | POLB (0.71) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL5368759 | 0.89 | MAPT (1.00) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7059470 | 0.88 | IKBKB (0.69) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7054758 | 0.88 | KDM4E (0.70) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL1563671 | 0.88 | NPSR1 (0.70) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL2157496 | 0.87 | MAPT (0.76) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7057270 | 0.86 | MAPT (0.76) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7052667 | 0.85 | IKBKB (0.78) | MAPTKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL3070348 | 0.85 | IKBKB (0.82) | MAPTIKBKBPOLB | |
| SCHEMBL1382301 | 0.85 | IKBKB (1.00) | MAPTKDM4EALDH1A1LMNAIKBKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |