Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 11/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MAPT | P10636 | 2/20 | 0.63 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | PTPRF | P10586 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3070348 | 0.88 | IKBKB (0.82) | IKBKBMAPTPTPRFPTPN1JAK2 | |
| SCHEMBL1382301 | 0.88 | IKBKB (1.00) | IKBKBKDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL7059470 | 0.86 | IKBKB (0.69) | IKBKBKDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL7057264 | 0.85 | MAPT (0.80) | IKBKBKDM4ELMNAMAPTNPSR1 | |
| SCHEMBL7053685 | 0.85 | IKBKB (0.78) | IKBKBKDM4ELMNAMAPTRXFP1 | |
| SCHEMBL1382634 | 0.81 | IKBKB (1.00) | IKBKBKDM4ELMNAMAPTALDH1A1 | |
| SCHEMBL3064014 | 0.79 | IKBKB (0.83) | IKBKBMAPTPTPRFPTPN1CHEK1 | |
| SCHEMBL3075700 | 0.79 | POLB (0.71) | IKBKBMAPTPTPRFPTPN1JAK2 | |
| SCHEMBL4086105 | 0.79 | IKBKB (0.78) | IKBKBPTPRFPTPN1JAK2JAK3 | |
| SCHEMBL4639911 | 0.78 | KDM4E (0.67) | IKBKBKDM4ELMNAMAPTRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | claimed |
| WO-2003028731-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |