Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 18/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 18/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7055803 | 0.88 | MTNR1A (0.65) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL8822761 | 0.82 | MTNR1A (0.58) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL7051523 | 0.80 | MTNR1A (0.62) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL7058321 | 0.79 | MTNR1A (0.49) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL7051405 | 0.78 | MTNR1A (0.78) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL7056605 | 0.77 | MTNR1A (0.37) | MTNR1AMTNR1B | |
| SCHEMBL7055536 | 0.77 | MTNR1A (0.48) | MTNR1AMTNR1B | |
| SCHEMBL7055218 | 0.75 | MTNR1A (0.47) | MTNR1AMTNR1B | |
| SCHEMBL7055344 | 0.75 | MTNR1A (0.54) | MTNR1AMTNR1BTRPV1 | |
| SCHEMBL7055900 | 0.74 | MTNR1A (0.65) | MTNR1AMTNR1BTRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0656209-B1 | Melatonin derivatives for use in treating desynchronization disorders | LILLY CO ELI (US) | 2003-05-07 | — | — | EP | disclosed |
| EP-0655243-B1 | Melatonin derivatives for use in treating sleep disorders | LILLY CO ELI (US) | 2002-08-21 | — | — | EP | disclosed |
| US-6180657-B1 | SLEEP DISORDERS | ELI LILLY AND COMPANY | 2001-01-30 | — | — | US | disclosed |
| US-5770610-A | ADMINISTERING R-(+)-N-(2-METHYL-2-(5-METHOXY-6-CHLOROINDOL-3-YL)ETHYL) ACETAMIDE | ELI LILLY AND COMPANY (US) | 1998-06-23 | — | — | US | disclosed |
| US-5654325-A | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1997-08-05 | — | — | US | disclosed |
| WO-1997000069-A1 | MELATONIN AGONISTS FOR TREATING BENIGN PROSTATIC HYPERPLASIA | ELI LILLY AND COMPANY (US) | 1997-01-03 | — | — | WO | disclosed |
| EP-0748627-A2 | Melatonin agonists for use in the treatment of benign prostatic hyperplasia | ELI LILLY AND COMPANY (US) | 1996-12-18 | — | — | EP | disclosed |
| EP-0656209-A2 | Melatonin derivatives for use in treating desynchronization disorders | ELI LILLY AND COMPANY (US) | 1995-06-07 | — | — | EP | disclosed |
| EP-0655243-A2 | Melatonin derivatives for use in treating sleep disorders | ELI LILLY AND COMPANY (US) | 1995-05-31 | — | — | EP | disclosed |
| US-4997845-A | β-alkylmelatonins as ovulation inhibitors | ELI LILLY AND COMPANY (US) | 1991-03-05 | — | — | US | disclosed |