SCHEMBL7057728

SCHEMBL7057728

CCCCCCCCCCC(C(=O)O[SiH3])(c1ccccc1)c1ccccc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN1A P35498 3/20 0.48
SCN2A Q99250 3/20 0.48
SCN3A Q9NY46 3/20 0.48
LMNA P02545 3/20 0.48
CYP1A2 P05177 2/20 0.48
CYP3A4 P08684 2/20 0.48
CYP2D6 P10635 2/20 0.48
CYP2C9 P11712 2/20 0.48
CYP2C19 P33261 2/20 0.48
TSHR P16473 2/20 0.48
NFKB1 P19838 1/20 0.48
MTOR P42345 1/20 0.48
RAB9A P51151 1/20 0.48
SIGMAR1 Q99720 1/20 0.48
KDM4E B2RXH2 1/20 0.47
MEN1 O00255 1/20 0.47
NR1I2 O75469 1/20 0.47
CYP1A1 P04798 1/20 0.47
CYP2E1 P05181 1/20 0.47
CYP2C8 P10632 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7056880 1.00 SCN1A (0.48) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL4582562 0.86 SCN1A (0.53) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL26923528 0.86 SCN1A (0.47) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL3518062 0.84 OPRM1 (0.44) SCN1ASCN2ASCN3ALMNACYP1A2
Bromide SCHEMBL10984916 0.84 SCN1A (0.45) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL7025068 0.83 OPRM1 (0.46) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL7005929 0.83 OPRM1 (0.46) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL5147680 0.83 OPRM1 (0.46) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL20564993 0.83 OPRM1 (0.46) SCN1ASCN2ASCN3ALMNACYP1A2
SCHEMBL3923946 0.83 OPRM1 (0.46) SCN1ASCN2ASCN3ALMNACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1006118-B1 Method for synthesizing organosilicon compounds that contain a group bonded to silicon across the SI-C bond DOW CORNING ASIA LTD (JP) 2003-05-07 EP disclosed
US-6175031-B1 PLATINUM-CATALYZED HYDROSILYLATION BETWEEN SIH-SUBSTITUTED SILICON COMPOUNDS AND UNSATURATED GROUP-FUNCTIONAL ORGANIC OR ORGANOSILICON COMPOUNDS IN PRESENCE OF A (ACYLOXY)-FUNCTIONAL HYDROGENSILANE COMPOUND OR ACID AND HYDRO(ALKOXY)SILANE DOW CORNING ASIA, LTD. (JP) 2001-01-16 US disclosed
US-6111126-A Method for synthesizing organosilicon compounds that contain a functional group bonded to silicon across the Si-C bond DOW CORNING ASIA, LTD. (JP) 2000-08-29 US disclosed
EP-1006118-A2 Method for synthesizing organosilicon compounds that contain a group bonded to silicon across the SI-C bond Dow Corning Asia, Ltd. (JP) 2000-06-07 EP disclosed