Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 3/20 | 0.37 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.34 |
| ▸ | DRD1 | P21728 | 3/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6885 | 0.80 | LPAR1 (0.55) | LPAR1LPAR3HRH1ABCC3ABCC4 | |
| SCHEMBL6285 | 0.77 | LPAR1 (0.48) | LPAR1ALDH1A1SLC6A4KCNH2LMNA | |
| SCHEMBL1166 | 0.76 | LPAR1 (0.47) | LPAR1LPAR3ALDH1A1SLC6A4LMNA | |
| SCHEMBL7057 | 0.75 | L3MBTL1 (0.37) | LPAR1LPAR3ALDH1A1LMNADRD3 | |
| SCHEMBL6972 | 0.72 | LPAR1 (0.38) | LPAR1LPAR3ALDH1A1LMNAABCC3 | |
| SCHEMBL6971 | 0.72 | LPAR1 (0.38) | LPAR1LPAR3ALDH1A1LMNAABCC3 | |
| SCHEMBL1691 | 0.71 | LPAR1 (0.40) | LPAR1LPAR3ALDH1A1ABCC3ABCC4 | |
| SCHEMBL1690 | 0.71 | LPAR1 (0.40) | LPAR1LPAR3ALDH1A1ABCC3ABCC4 | |
| SCHEMBL27886983 | 0.70 | LPAR1 (0.34) | LPAR1LPAR3ALDH1A1ABCC3ABCC4 | |
| SCHEMBL27880057 | 0.70 | LPAR1 (0.40) | LPAR1LPAR3ALDH1A1ABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2483252-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | Amira Pharmaceuticals, Inc. (US) | 2012-08-08 | — | — | EP | disclosed |
| WO-2011041694-A2 | COMPOUNDS AS LYSOPHOSPHATIDIC ACID RECEPTOR ANTAGONISTS | AMIRA PHARMACEUTICALS, INC. (US) | 2011-04-07 | — | — | WO | disclosed |