Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 5/20 | 0.41 |
| ▸ | HRH1 | P35367 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | HEXA | P06865 | 2/20 | 0.38 |
| ▸ | HEXB | P07686 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29561558 | 0.87 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAAALPLPOLB | |
| SCHEMBL5443297 | 0.87 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAAALPLPOLB | |
| SCHEMBL10082145 | 0.80 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAAALPLPOLB | |
| SCHEMBL68721 | 0.80 | ALDH1A1 (0.45) | ALDH1A1KDM4EGAAALPLPOLB | |
| SCHEMBL5028346 | 0.79 | ALDH1A1 (0.58) | ALDH1A1KDM4EGAAPOLBHSD17B10 | |
| SCHEMBL1557163 | 0.75 | MEN1 (0.48) | ALDH1A1KDM4EGAAPOLBHSD17B10 | |
| SCHEMBL7250955 | 0.74 | ALDH1A1 (0.49) | ALDH1A1KDM4EGAAALPLPOLB | |
| SCHEMBL14357449 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KDM4EGAAPOLBHSD17B10 | |
| SCHEMBL522064 | 0.72 | HRH1 (0.56) | HRH1 | |
| SCHEMBL14007500 | 0.72 | ALDH1A1 (0.38) | ALDH1A1KDM4EGAAALPLPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |