Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 12/20 | 0.56 |
| ▸ | GBA1 | P04062 | 10/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | GRM5 | P41594 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 8/20 | 0.47 |
| ▸ | TP53 | P04637 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.44 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6630826 | 0.79 | RAB9A (0.71) | RAB9AGBA1MEN1KMT2APOLB | |
| SCHEMBL5338101 | 0.78 | RAB9A (0.53) | RAB9AGBA1MEN1KMT2APOLB | |
| SCHEMBL5345140 | 0.76 | CDK5 (0.69) | RAB9AGBA1MEN1KMT2APOLB | |
| SCHEMBL14353530 | 0.73 | RAB9A (1.00) | RAB9AGBA1MEN1KMT2APOLB | |
| SCHEMBL14558373 | 0.70 | CDK5 (0.53) | RAB9AGBA1KMT2APOLBGRM5 | |
| SCHEMBL5338684 | 0.70 | CDK5 (0.74) | RAB9AMEN1KMT2ANPC1SMN1; SMN2 | |
| SCHEMBL14558383 | 0.69 | CDK5 (0.55) | RAB9AGRM5NPC1SMN1; SMN2CDK5 | |
| SCHEMBL14558360 | 0.68 | CDK5 (0.57) | RAB9AMEN1KMT2ANPC1TP53 | |
| SCHEMBL7059452 | 0.68 | RAB9A (0.52) | RAB9AGBA1MEN1KMT2APOLB | |
| SCHEMBL14558395 | 0.67 | CDK5 (0.53) | RAB9AGRM5NPC1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |