Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 7/20 | 0.73 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.73 |
| ▸ | IKBKB | O14920 | 3/20 | 0.60 |
| ▸ | JAK2 | O60674 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7051438 | 0.88 | CHEK1 (0.82) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL7052328 | 0.88 | CHEK1 (0.78) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL7055999 | 0.87 | CHEK1 (0.72) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL5898667 | 0.87 | IKBKB (0.74) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL7056909 | 0.86 | IKBKB (0.82) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL7055226 | 0.84 | CHEK1 (1.00) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL7055239 | 0.79 | CHEK1 (1.00) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL7058336 | 0.79 | CHEK1 (0.66) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL13930115 | 0.79 | IKBKB (0.78) | CHEK1MAP4K4IKBKBJAK2JAK3 | |
| SCHEMBL7055995 | 0.78 | CHEK1 (0.62) | CHEK1MAP4K4IKBKBJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |