Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 8/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | IKBKB | O14920 | 4/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | EIF2AK2 | P19525 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 2/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7058327 | 0.89 | IKBKB (0.58) | CHEK1MAP4K4IKBKBJAK2MEN1 | |
| SCHEMBL7058543 | 0.88 | CHEK1 (0.50) | CHEK1MAP4K4IKBKBMEN1KMT2A | |
| SCHEMBL7057671 | 0.88 | CHEK1 (0.56) | CHEK1MAP4K4IKBKBJAK2HDAC6 | |
| SCHEMBL7055932 | 0.86 | CHEK1 (0.59) | CHEK1MAP4K4IKBKBJAK2MEN1 | |
| SCHEMBL7052328 | 0.86 | CHEK1 (0.78) | CHEK1MAP4K4IKBKBJAK2NPC1 | |
| SCHEMBL7055235 | 0.84 | CHEK1 (0.62) | CHEK1MAP4K4IKBKBHDAC6NPC1 | |
| SCHEMBL7051467 | 0.84 | CHEK1 (0.56) | CHEK1MAP4K4IKBKBNPC1MAPT | |
| SCHEMBL7052959 | 0.80 | CHEK1 (0.49) | CHEK1MAP4K4IKBKBTDP1HDAC6 | |
| SCHEMBL7050462 | 0.80 | CHEK1 (0.54) | CHEK1MAP4K4IKBKBHDAC6NPC1 | |
| SCHEMBL7055165 | 0.80 | CHEK1 (0.54) | CHEK1MAP4K4IKBKBTDP1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003029241-A1 | CHK1 KINASE INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 2003-04-10 | — | — | WO | disclosed |