SCHEMBL7059653

SCHEMBL7059653

C=CCN(CC=C)c1ccc(CCC(=O)C(C)C)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHKA P35790 1/20 0.44
BCHE P06276 2/20 0.38
ACHE P22303 2/20 0.38
PTPN1 P18031 2/20 0.36
CNR2 P34972 2/20 0.36
SMN1; SMN2 Q16637 3/20 0.35
GMNN O75496 1/20 0.35
ALDH1A1 P00352 1/20 0.35
LMNA P02545 1/20 0.35
CYP2D6 P10635 1/20 0.35
MAPT P10636 1/20 0.35
GABRA1 P14867 1/20 0.35
TSHR P16473 1/20 0.35
NFKB1 P19838 1/20 0.35
THPO P40225 1/20 0.35
GABRA2 P47869 1/20 0.35
GABRB2 P47870 1/20 0.35
PMP22 Q01453 1/20 0.35
HIF1A Q16665 1/20 0.35
SLCO1B3 Q9NPD5 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21099895 0.79 ALDH1A1 (0.45) ALDH1A1MEN1KMT2A
SCHEMBL14810407 0.76 SMN1; SMN2 (0.61) CHKASMN1; SMN2GMNNALDH1A1LMNA
SCHEMBL7059652 0.75 KMT2A (0.38) CHKAACHEPTPN1CNR2SMN1; SMN2
SCHEMBL15794089 0.74 CHKA (0.54) CHKACNR2SMN1; SMN2GMNNALDH1A1
SCHEMBL6771650 0.73 CNR2 (0.45) CHKACNR2ALDH1A1MAPTAOC3
SCHEMBL19658332 0.72 ALDH1A1 (0.59) SMN1; SMN2ALDH1A1LMNAMAPTMEN1
SCHEMBL2625210 0.72 FFAR1 (0.51) SMN1; SMN2ALDH1A1LMNAMAPT
SCHEMBL106904 0.72 ESR1 (0.50) ALDH1A1LMNACYP2D6MAPTTSHR
SCHEMBL9320624 0.71 HDAC3 (0.42) CHKAPTPN1SMN1; SMN2ALDH1A1LMNA
SCHEMBL851567 0.71 CHKA (0.50) CHKAPTPN1CNR2SMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1015441-B1 PROCESS TO PRODUCE 4-HYDROXY-2-OXO-PYRANE DERIVATIVES USEFUL AS PROTEASE INHIBITORS UPJOHN CO (US) 2004-05-12 EP disclosed
US-6265604-B1 AS PROTEASE INHIBITOR USEFUL IN TREATING HUMANS INFECTED WITH THE HIV VIRUS PHARMACIA & UPJOHN COMPANY 2001-07-24 US disclosed
EP-1015441-A1 PROCESS TO PRODUCE 4-HYDROXY-2-OXO-PYRANE DERIVATIVES USEFUL AS PROTEASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 2000-07-05 EP disclosed
US-6077963-A Process to produce a protease inhibitor PHARMACIA & UPJOHN COMPANY (US) 2000-06-20 US disclosed
WO-1999012919-A1 PROCESS TO PRODUCE 4-HYDROXY-2-OXO-PYRANE DERIVATES USEFUL AS PROTEASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-03-18 WO disclosed