Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1515349 | 0.82 | TSHR (0.50) | CYP2C19TSHR | |
| SCHEMBL5651938 | 0.82 | TSHR (0.50) | CYP2C19TSHR | |
| SCHEMBL5651945 | 0.82 | TSHR (0.50) | CYP2C19TSHR | |
| SCHEMBL5652143 | 0.79 | MAOB (0.37) | — | |
| SCHEMBL4968601 | 0.79 | SLC6A2 (0.38) | — | |
| SCHEMBL4971437 | 0.79 | CYP3A4 (0.37) | CYP1A2CYP2C19MAPT | |
| SCHEMBL4968605 | 0.79 | SLC6A2 (0.38) | — | |
| SCHEMBL5654186 | 0.79 | MAOB (0.37) | — | |
| SCHEMBL4972142 | 0.79 | MAOB (0.37) | — | |
| SCHEMBL4971432 | 0.79 | CYP3A4 (0.37) | CYP1A2CYP2C19MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |
| US-5773437-A | UROGENITAL DISORDERS SUCH AS DYSURIA | NIPPON CHEMIPHAR CO., LTD. (JP) | 1998-06-30 | — | — | US | disclosed |