Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK5 | Q00535 | 12/20 | 0.42 |
| ▸ | CDK5R1 | Q15078 | 12/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.33 |
| ▸ | CDK2 | P24941 | 3/20 | 0.33 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.33 |
| ▸ | GPR142 | Q7Z601 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.31 |
| ▸ | BACE1 | P56817 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5344552 | 0.84 | CDK5 (0.44) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5348210 | 0.82 | CDK5 (0.50) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5341200 | 0.79 | CDK5 (0.60) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5338959 | 0.78 | CDK5 (0.52) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL6629791 | 0.78 | CDK5 (0.54) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL7061478 | 0.78 | CDK5 (0.44) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL14558417 | 0.78 | CDK5 (0.46) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL7059759 | 0.77 | CDK5 (0.49) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5343066 | 0.76 | CDK5 (0.51) | CDK5CDK5R1ROCK1DYRK1ACCNA2 | |
| SCHEMBL5341862 | 0.76 | CDK5 (0.46) | CDK5CDK5R1ROCK1CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |