Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.62 |
| ▸ | HTR2C | P28335 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 3/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.35 |
| ▸ | BAD | Q92934 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | PNMT | P11086 | 1/20 | 0.33 |
| ▸ | CD44 | P16070 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | DRD5 | P21918 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrothiophene SCHEMBL17761203 | 0.95 | TSHR (0.68) | TSHRHTR2CHPGDL3MBTL1MAOB | |
| SCHEMBL7065099 | 0.93 | TSHR (0.57) | TSHRHTR2CHPGDL3MBTL1MAOB | |
| SCHEMBL7062021 | 0.87 | TSHR (0.63) | TSHRHTR2CHPGDL3MBTL1MAOB | |
| SCHEMBL4860332 | 0.87 | TSHR (0.53) | TSHRHTR2CMAOBCYP2A6MAOA | |
| SCHEMBL7334563 | 0.87 | TSHR (0.53) | TSHRHTR2CMAOBCYP2A6MAOA | |
| O-Xylene SCHEMBL18691956 | 0.85 | TSHR (0.54) | TSHRHTR2CHPGDL3MBTL1MAOB | |
| SCHEMBL7064609 | 0.84 | TSHR (0.59) | TSHRHTR2CHPGDL3MBTL1MAOB | |
| SCHEMBL7066238 | 0.82 | TSHR (0.56) | TSHRHTR2CHPGDL3MBTL1MAOB | |
| SCHEMBL8355 | 0.79 | TSHR (1.00) | TSHRHTR2CHPGDL3MBTL1MAOB | |
| SCHEMBL11645158 | 0.79 | TSHR (1.00) | TSHRHTR2CHPGDL3MBTL1MAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0901787-B1 | Stabilized pharmaceutical composition | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2003-05-28 | — | — | EP | disclosed |
| EP-0952826-B1 | IDEBENONE CONTAINING COMBINATION AGENT FOR TREATING ALZHEIMER'S DISEASE | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2001-11-14 | — | — | EP | disclosed |
| US-6187340-B1 | TABLETS WITH COATINGS THAT PROTECT FROM LIGHT | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-02-13 | — | — | US | disclosed |
| EP-0952826-A1 | IDEBENONE CONTAINING COMBINATION AGENT FOR TREATING ALZHEIMER'S DISEASE | Takeda Chemical Industries, Ltd. (JP) | 1999-11-03 | — | — | EP | disclosed |
| US-5962535-A | SYNERGISTIC MIXTURE OF IDEBENONE AND ACETYLCHOLINESTERASE INHIBITOR | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1999-10-05 | — | — | US | disclosed |
| EP-0901787-A1 | Stabilized pharmaceutical composition | Takeda Chemical Industries, Ltd. (JP) | 1999-03-17 | — | — | EP | disclosed |
| WO-1998031356-A1 | IDEBENONE CONTAINING COMBINATION AGENT FOR TREATING ALZHEIMER'S DISEASE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-07-23 | — | — | WO | disclosed |
| EP-0487071-B1 | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-07-05 | — | — | EP | disclosed |
| US-5273974-A | Condensed heterocyclic compounds, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-12-28 | — | — | US | disclosed |
| EP-0487071-A1 | Condensed heterocyclic compounds, their production and use | Takeda Chemical Industries, Ltd. (JP) | 1992-05-27 | — | — | EP | disclosed |