Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.40 |
| ▸ | PNMT | P11086 | 1/20 | 0.40 |
| ▸ | CD44 | P16070 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 3/20 | 0.39 |
| ▸ | DRD2 | P14416 | 2/20 | 0.39 |
| ▸ | DRD1 | P21728 | 2/20 | 0.39 |
| ▸ | DRD4 | P21917 | 2/20 | 0.39 |
| ▸ | DRD5 | P21918 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.35 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4860332 | 1.00 | TSHR (0.53) | TSHRHTR2CCES1MAOBCYP2A6 | |
| SCHEMBL7065099 | 0.89 | TSHR (0.57) | TSHRHTR2CCES1MAOBCYP2A6 | |
| SCHEMBL7062020 | 0.87 | TSHR (0.62) | TSHRHTR2CCES1MAOBCYP2A6 | |
| SCHEMBL255957 | 0.86 | TSHR (0.46) | TSHRHTR2CCES1MAOBCYP2A6 | |
| SCHEMBL7062021 | 0.82 | TSHR (0.63) | TSHRHTR2CCES1MAOBCYP2A6 | |
| Tetrahydrothiophene SCHEMBL17761203 | 0.80 | TSHR (0.68) | TSHRHTR2CCES1MAOBCYP2A6 | |
| SCHEMBL29351986 | 0.75 | — | — | |
| SCHEMBL33555 | 0.75 | — | — | |
| SCHEMBL34906 | 0.75 | — | — | |
| SCHEMBL4465325 | 0.75 | TSHR (0.71) | TSHRHTR2CCES1MAOBCYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0519428-B1 | Cyclodextrin compositions with fumagillol derivates | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2000-09-20 | — | — | EP | disclosed |
| EP-1004318-A2 | Cyclodextrin composition | Takeda Chemical Industries, Ltd. (JP) | 2000-05-31 | — | — | EP | disclosed |
| EP-0658342-B1 | Antineoplastic pharmaceutical composition containing a fumagillol derivative and a platinum complex | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1999-03-17 | — | — | EP | disclosed |
| US-5846562-A | Oral composition of fumagillol derivative | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-12-08 | — | — | US | disclosed |
| US-5710148-A | FUMAGILLOL DERIVATIVES | SENJU PHARMACEUTICALS CO., LTD. (JP) | 1998-01-20 | — | — | US | disclosed |
| EP-0799616-A1 | Oral composition comprising a fumagillol derivative | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-08 | — | — | EP | disclosed |
| EP-0602586-B1 | Stable pharmaceutical composition of fumagillol derivatives | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-06-04 | — | — | EP | disclosed |
| EP-0461427-B1 | Cyclodextrin complex | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1997-02-19 | — | — | EP | disclosed |
| EP-0730863-A2 | A corneal opacification inhibitory composition comprising a fumagillol derivative | Senju Pharmaceutical Co., Ltd. (JP) | 1996-09-11 | — | — | EP | disclosed |
| US-5536623-A | 6-O-/N-CHLOROACETYLCARBAMOYL/FUMAGILLOL | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-07-16 | — | — | US | disclosed |
| US-5422363-A | Therapy of cancer, diabetes and vision disorders | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 1995-06-06 | — | — | US | disclosed |
| EP-0602586-A2 | Stable pharmaceutical composition of fumagillol derivatives | Takeda Chemical Industries, Ltd. (JP) | 1994-06-22 | — | — | EP | disclosed |
| EP-0555693-A1 | Method of producing highly watersoluble cyclodextrin complex | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-08-18 | — | — | EP | disclosed |
| US-5202352-A | Antitumor agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-04-13 | — | — | US | disclosed |
| US-5196406-A | Antitumor, antiinflammatory | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-03-23 | — | — | US | disclosed |
| US-5180735-A | Antitumor agents, angiogenesis inhibitors | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-01-19 | — | — | US | disclosed |
| EP-0519428-A2 | Cyclodextrin composition | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1992-12-23 | — | — | EP | disclosed |
| EP-0470569-A1 | Intravascular embolizing agent containing angiogenesis inhibiting substance | Takeda Chemical Industries, Ltd. (JP) | 1992-02-12 | — | — | EP | disclosed |
| EP-0461427-A2 | Cyclodextrin complex | Takeda Chemical Industries, Ltd. (JP) | 1991-12-18 | — | — | EP | disclosed |
| EP-0415294-A2 | Cyclohexanol derivatives, production and use thereof | Takeda Chemical Industries, Ltd. (JP) | 1991-03-06 | — | — | EP | disclosed |