SCHEMBL7062330

SCHEMBL7062330

CCOP(=O)(OCC)C(C)(C)C(=O)/C=C/c1cc(C(C)(C)C)c(OC)c(C(C)(C)C)c1

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TNFRSF1A P19438 4/20 0.45
HMGCR P04035 3/20 0.41
NR1I2 O75469 1/20 0.41
GABBR2 O75899 1/20 0.37
GABBR1 Q9UBS5 1/20 0.37
HTR1A P08908 3/20 0.36
HTR2C P28335 3/20 0.36
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 2/20 0.36
GAA P10253 1/20 0.36
HTT P42858 1/20 0.36
HPGD P15428 1/20 0.36
HSD17B10 Q99714 1/20 0.36
KMT2A Q03164 1/20 0.36
LMNA P02545 1/20 0.36
MAPT P10636 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
BACE1 P56817 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.34
PSMB11 A5LHX3 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7062332 1.00 TNFRSF1A (0.45) TNFRSF1AHMGCRNR1I2GABBR2GABBR1
SCHEMBL9276664 0.88 HMGCR (0.55) TNFRSF1AHMGCRNR1I2GABBR2GABBR1
SCHEMBL9276670 0.88 HMGCR (0.55) TNFRSF1AHMGCRNR1I2GABBR2GABBR1
SCHEMBL7060718 0.87 TNFRSF1A (0.49) TNFRSF1AGABBR2GABBR1HTR1AHTR2C
SCHEMBL7060721 0.87 TNFRSF1A (0.49) TNFRSF1AGABBR2GABBR1HTR1AHTR2C
SCHEMBL7065034 0.83 TNFRSF1A (0.50) TNFRSF1AGABBR2GABBR1HTR1AHTR2C
SCHEMBL6916935 0.83 TNFRSF1A (0.50) TNFRSF1AGABBR2GABBR1HTR1AHTR2C
SCHEMBL5668624 0.82 HMGCR (0.53) HMGCRNR1I2GABBR2GABBR1ALDH1A1
SCHEMBL5668629 0.82 HMGCR (0.53) HMGCRNR1I2GABBR2GABBR1ALDH1A1
SCHEMBL6910433 0.81 TNFRSF1A (0.45) TNFRSF1AHMGCRNR1I2GABBR2GABBR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004026245-A2 SUBSTITUTED PHOSPHONATE COMPOUNDS HAVING BONE ANABOLIC ACTIVITY ILEX ONCOLOGY RESEARCH, SARL (CH) 2004-04-01 WO claimed