Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR4 | P61073 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
| ▸ | ACKR3 | P25106 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CRHBP | P24387 | 1/20 | 0.35 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5354718 | 0.84 | CDK5 (0.52) | CXCR4CDK5CDK5R1ALDH1A1FAAH | |
| SCHEMBL7062808 | 0.74 | CXCR4 (0.40) | CXCR4SMN1; SMN2TDP1ALDH1A1KDM4E | |
| SCHEMBL1427945 | 0.74 | SMN1; SMN2 (0.46) | SMN1; SMN2TDP1ALDH1A1KDM4ECHRNA7 | |
| SCHEMBL18157904 | 0.73 | CXCR4 (0.66) | CXCR4SMN1; SMN2TDP1ALDH1A1KDM4E | |
| SCHEMBL839038 | 0.73 | FAAH (0.53) | CXCR4SMN1; SMN2TDP1ALDH1A1KDM4E | |
| SCHEMBL12726809 | 0.72 | SMN1; SMN2 (0.47) | SMN1; SMN2ALDH1A1KDM4ECHRNA7POLB | |
| Hydrochloric Acid SCHEMBL29604003 | 0.72 | CXCR4 (0.63) | CXCR4SMN1; SMN2TDP1ALDH1A1KDM4E | |
| Bromide SCHEMBL29605492 | 0.72 | CXCR4 (0.63) | CXCR4SMN1; SMN2TDP1ALDH1A1KDM4E | |
| SCHEMBL20609083 | 0.72 | CXCR4 (0.68) | CXCR4SMN1; SMN2TDP1ALDH1A1KDM4E | |
| SCHEMBL5343458 | 0.72 | CDK5 (0.52) | CDK5CDK5R1SMN1; SMN2ACKR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1309589-A2 | UREA COMPOUNDS AND METHODS OF USES | Amgen Inc. (US) | 2003-05-14 | — | — | EP | disclosed |
| WO-2002014311-A2 | UREA COMPOUNDS AND METHODS OF USES | AMGEN INC. (US) | 2002-02-21 | — | — | WO | disclosed |