Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP13 | P45452 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.36 |
| ▸ | UBE2N | P61088 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TACR1 | P25103 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6343341 | 0.85 | EPHX1 (0.49) | EPHX1GAACYP1A2CYP2D6PKM | |
| SCHEMBL6937352 | 0.76 | EPHX1 (0.51) | EPHX1GAASMN1; SMN2MMP9MMP8 | |
| SCHEMBL12718845 | 0.73 | EPHX1 (0.59) | EPHX1CYP1A2CYP2D6PKMSMN1; SMN2 | |
| SCHEMBL3353282 | 0.72 | EPHX1 (0.63) | EPHX1GAACYP1A2CYP2D6PKM | |
| SCHEMBL2587234 | 0.72 | EPHX1 (0.63) | EPHX1GAACYP1A2CYP2D6PKM | |
| SCHEMBL27446150 | 0.72 | EPHX1 (0.54) | EPHX1CYP1A2CYP2D6PKMSMN1; SMN2 | |
| SCHEMBL6904222 | 0.72 | EPHX1 (0.58) | EPHX1GAACHRM1TDP1ALOX5 | |
| SCHEMBL4494122 | 0.72 | EPHX1 (0.58) | EPHX1GAACHRM1TDP1ALOX5 | |
| Hydrochloric Acid SCHEMBL3353959 | 0.71 | EPHX1 (0.61) | EPHX1GAACYP1A2CYP2D6PKM | |
| SCHEMBL16881947 | 0.70 | EPHX1 (0.66) | EPHX1CYP1A2CYP2D6PKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1032424-B9 | COMBINATION OF AN ALDOSE REDUCTASE INHIBITOR AND A GLYCOGEN PHOSPHORYLASE INHIBITOR | PFIZER PROD INC (US) | 2004-10-06 | — | — | EP | claimed |
| EP-1032424-B1 | COMBINATION OF AN ALDOSE REDUCTASE INHIBITOR AND A GLYCOGEN PHOSPHORYLASE INHIBITOR | PFIZER PROD INC (US) | 2001-09-12 | — | — | EP | claimed |