Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 15/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 13/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.40 |
| ▸ | ABCC9 | O60706 | 1/20 | 0.36 |
| ▸ | KCNJ11 | Q14654 | 1/20 | 0.36 |
| ▸ | S100B | P04271 | 1/20 | 0.35 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.35 |
| ▸ | ITGAV | P06756 | 1/20 | 0.35 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.34 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.34 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6817701 | 0.82 | CXCR2 (0.56) | CXCR2CXCR1 | |
| SCHEMBL6817607 | 0.79 | CXCR2 (0.53) | CXCR2CXCR1ABCC9KCNJ11 | |
| SCHEMBL7063167 | 0.77 | CXCR2 (0.46) | CXCR2CXCR1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7063170 | 0.77 | CXCR2 (0.46) | CXCR2CXCR1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL6922794 | 0.75 | CXCR1 (0.47) | CXCR2CXCR1TRPV1 | |
| SCHEMBL5595003 | 0.73 | CXCR2 (0.66) | CXCR2CXCR1 | |
| SCHEMBL6918837 | 0.72 | CXCR1 (0.47) | CXCR2CXCR1 | |
| SCHEMBL7212596 | 0.68 | CXCR2 (0.52) | CXCR2CXCR1 | |
| SCHEMBL7514963 | 0.67 | CXCR2 (0.73) | CXCR2CXCR1TRPV1 | |
| SCHEMBL7212775 | 0.67 | CXCR2 (0.51) | CXCR2CXCR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1191934-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-1191934-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| WO-2000076516-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |