Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCR2 | P25025 | 5/20 | 0.46 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | CX3CR1 | P49238 | 1/20 | 0.37 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.36 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.36 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.34 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.34 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.34 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7063170 | 1.00 | CXCR2 (0.46) | CXCR2CXCR1MEN1KMT2ACX3CR1 | |
| SCHEMBL5595003 | 0.83 | CXCR2 (0.66) | CXCR2CXCR1MEN1KMT2ACX3CR1 | |
| SCHEMBL6817696 | 0.81 | CXCR2 (0.70) | CXCR2CXCR1MEN1KMT2A | |
| SCHEMBL6817693 | 0.81 | CXCR2 (0.70) | CXCR2CXCR1MEN1KMT2A | |
| SCHEMBL6817474 | 0.81 | CXCR2 (0.65) | CXCR2CXCR1MEN1KMT2ALMNA | |
| SCHEMBL6817602 | 0.81 | CXCR2 (0.65) | CXCR2CXCR1MEN1KMT2ALMNA | |
| SCHEMBL7063173 | 0.77 | CXCR2 (0.46) | CXCR2CXCR1TAS1R3TAS1R1TAS1R2 | |
| SCHEMBL7489083 | 0.76 | CXCR2 (0.69) | CXCR2CXCR1MEN1KMT2ACX3CR1 | |
| SCHEMBL6136721 | 0.74 | CXCR2 (0.46) | CXCR2CXCR1MEN1KMT2ATAS1R3 | |
| SCHEMBL6129952 | 0.74 | CXCR2 (0.45) | CXCR2CXCR1MEN1KMT2ACX3CR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6204294-B1 | GUANIDINE CONTAINING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2001-03-20 | — | — | US | claimed |
| EP-1191934-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2004-02-04 | — | — | EP | disclosed |
| EP-0929302-A4 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 2002-10-31 | — | — | EP | disclosed |
| EP-1191934-A1 | IL-8 RECEPTOR ANTAGONISTS | SmithKline Beecham Corporation (US) | 2002-04-03 | — | — | EP | disclosed |
| US-6204294-B1 | GUANIDINE CONTAINING COMPOUNDS | SMITHKLINE BEECHAM CORPORATION | 2001-03-20 | — | — | US | disclosed |
| WO-2000076516-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-12-21 | — | — | WO | disclosed |
| EP-0929302-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998006397-A1 | IL-8 RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-19 | — | — | WO | disclosed |