Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 10/20 | 0.65 |
| ▸ | AKR1C2 | P52895 | 9/20 | 0.65 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.65 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.65 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.65 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.65 |
| ▸ | FABP3 | P05413 | 1/20 | 0.62 |
| ▸ | FABP4 | P15090 | 1/20 | 0.62 |
| ▸ | CDC25B | P30305 | 2/20 | 0.62 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.56 |
| ▸ | TTR | P02766 | 1/20 | 0.56 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6141423 | 0.87 | AKR1C3 (0.70) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL14376023 | 0.86 | AKR1C3 (0.82) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL22720189 | 0.85 | AKR1C3 (0.71) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL6141457 | 0.84 | AKR1C3 (0.70) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL21027769 | 0.84 | CDC25B (0.63) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL10834828 | 0.82 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL31494629 | 0.82 | AKR1C3 (0.67) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL24021597 | 0.81 | AKR1C3 (0.64) | AKR1C3AKR1C2AKR1B10AKR1B1AKR1C4 | |
| SCHEMBL16489012 | 0.81 | EGFR (0.66) | AKR1C3AKR1C2AKR1B10AKR1C1FABP3 | |
| SCHEMBL17363157 | 0.81 | DHODH (0.69) | CLCN2MEN1KMT2AMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1313696-A2 | AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ABBOTT LABORATORIES (US) | 2003-05-28 | — | — | EP | disclosed |
| US-20020035137-A1 | Amino (oxo) acetic acid protein tyrosine phosphatase inhibitors | ABBOTT LABORATORIES | 2002-03-21 | — | — | US | disclosed |
| WO-2002018323-A2 | AMINO(OXO)ACETIC ACID PROTEIN TYROSINE PHOSPHATASE INHIBITORS | ABBOTT LABORATORIES (US) | 2002-03-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020035137-A1 | Amino (oxo) acetic acid protein tyrosine phosphatase inhibitors | PPM1A, PTPRO, PTP4A1 | AKR1C3 1253/4885AKR1C2 886/4885AKR1B10 677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.