Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 15/20 | 1.00 |
| ▸ | MMP2 | P08253 | 11/20 | 1.00 |
| ▸ | MMP3 | P08254 | 11/20 | 1.00 |
| ▸ | PDE4A | P27815 | 6/20 | 0.72 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.72 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.72 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.72 |
| ▸ | MMP13 | P45452 | 7/20 | 0.67 |
| ▸ | MMP9 | P14780 | 4/20 | 0.67 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.67 |
| ▸ | MMP7 | P09237 | 4/20 | 0.66 |
| ▸ | MMP12 | P39900 | 4/20 | 0.66 |
| ▸ | ACE | P12821 | 3/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7207044 | 0.86 | MMP1 (0.76) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL20444027 | 0.85 | MMP1 (0.72) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6819965 | 0.84 | PDE4A (1.00) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6820122 | 0.82 | MMP1 (0.74) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL8412098 | 0.81 | MMP1 (0.69) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7208693 | 0.81 | MMP1 (0.68) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL1847769 | 0.81 | MMP1 (1.00) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6927179 | 0.81 | MMP1 (1.00) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6824204 | 0.80 | PDE4A (1.00) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7213401 | 0.80 | MMP1 (0.66) | MMP1MMP2MMP3PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871439-B1 | SUBSTITUTED (ARYL, HETEROARYL, ARYLMETHYL OR HETEROARYLMETHYL) HYDROXAMIC ACID COMPOUNDS | AVENTIS PHARMA INC (US) | 2004-03-31 | — | — | EP | disclosed |
| EP-0871439-A4 | SUBSTITUTED (ARYL, HETEROARYL, ARYLMETHYL OR HETEROARYLMETHYL) HYDROXAMIC ACID COMPOUNDS | RHONE POULENC RORER PHARMA (US) | 1999-07-21 | — | — | EP | disclosed |
| EP-0871439-A1 | SUBSTITUTED (ARYL, HETEROARYL, ARYLMETHYL OR HETEROARYLMETHYL) HYDROXAMIC ACID COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS, INC. (US) | 1998-10-21 | — | — | EP | disclosed |
| WO-1997024117-A1 | SUBSTITUTED (ARYL, HETEROARYL, ARYLMETHYL OR HETEROARYLMETHYL) HYDROXAMIC ACID COMPOUNDS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-07-10 | — | — | WO | disclosed |