Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 5/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.52 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29824898 | 0.83 | PDE4D (0.47) | PDE4APDE4DPDE4BPDE4CABCB11 | |
| SCHEMBL8664428 | 0.83 | PDE4D (0.47) | PDE4APDE4DPDE4BPDE4CABCB11 | |
| SCHEMBL2889923 | 0.78 | PDE4D (0.74) | PDE4APDE4DPDE4BPDE4CABCB11 | |
| SCHEMBL30084849 | 0.78 | PDE4D (0.74) | PDE4APDE4DPDE4BPDE4CABCB11 | |
| SCHEMBL2518447 | 0.77 | PDE4D (0.66) | PDE4APDE4DPDE4BPDE4CABCB11 | |
| SCHEMBL5539750 | 0.77 | PDE4D (0.51) | PDE4APDE4DPDE4BPDE4CABCB11 | |
| SCHEMBL8270336 | 0.77 | PDE4D (0.51) | PDE4APDE4DPDE4BPDE4CABCB11 | |
| SCHEMBL5017912 | 0.77 | PDE4B (0.71) | PDE4APDE4DPDE4BPDE4CABCB11 | |
| SCHEMBL717213 | 0.76 | PDE4D (0.66) | PDE4APDE4DPDE4BPDE4CABCB11 | |
| SCHEMBL71763 | 0.76 | PDE4A (0.47) | PDE4APDE4DPDE4BPDE4CABCB11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004098598-A1 | COMPOSITION COMPRISING ROFLUMILAST AND A TNFα ANTAGONIST | ALTANA PHARMA AG (DE) | 2004-11-18 | — | — | WO | disclosed |