⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1819667 | 0.73 | — | — | |
| SCHEMBL8987534 | 0.72 | ALDH1A1 (0.60) | — | |
| SCHEMBL7025240 | 0.71 | — | — | |
| SCHEMBL1818549 | 0.71 | — | — | |
| SCHEMBL1908110 | 0.69 | ALDH1A1 (0.56) | — | |
| SCHEMBL15354354 | 0.69 | — | — | |
| SCHEMBL4074364 | 0.69 | — | — | |
| SCHEMBL3387303 | 0.67 | — | — | |
| SCHEMBL13652849 | 0.67 | — | — | |
| SCHEMBL67637 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240360082-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2024-10-31 | — | — | US | disclosed |
| EP-4373809-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | Novartis AG (CH) | 2024-05-29 | — | — | EP | disclosed |
| CN-117980292-A | Substituted pyridone compounds for the treatment of orthomyxoviral infections | 诺华股份有限公司 | 2024-05-03 | — | — | CN | disclosed |
| WO-2023002443-A1 | SUBSTITUTED PYRIDONE COMPOUNDS USEFUL TO TREAT ORTHOMYXOVIRUS INFECTIONS | NOVARTIS AG (CH) | 2023-01-26 | — | — | WO | disclosed |
| US-9643964-B2 | 3-(2-aminopyrimidin-4-yl)-5-(3-hydroxypropynyl)-1H-pyrrolo[2,3-C]pyridine derivatives as NIK inhibitors for the treatment of cancer | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-09 | — | — | US | disclosed |
| US-20160075699-A1 | 3-(2-AMINOPYRIMIDIN-4-YL)-5-(3-HYDROXYPROPYNYL)-1H-PYRROLO[2,3-C]PYRIDINE DERIVATIVES AS NIK INHIBITORS FOR THE TREATMENT OF CANCER | JANSSEN PHARMACEUTICA N.V. (BE) | 2016-03-17 | — | — | US | disclosed |
| US-8883782-B2 | Spiro-tetracyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2014-11-11 | — | — | US | disclosed |
| US-8703987-B2 | Methods for preparing 2-methoxyisobutylisonitrile and tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate | Draximage Limited (IE) | 2014-04-22 | — | — | US | disclosed |
| EP-2328903-B1 | SPIRO-TETRACYCLIC RING COMPOUNDS AS BETASECRETASE MODULATORS AND METHODS OF USE | AMGEN INC (US) | 2014-03-05 | — | — | EP | disclosed |
| US-8426447-B2 | Spiro-tricyclic ring compounds as beta-secretase modulators and methods of use | AMGEN INC. (US) | 2013-04-23 | — | — | US | disclosed |
| US-20100087429-A1 | SPIRO-TRICYCLIC RING COMPOUNDS AS BETA-SECRETASE MODULATORS AND METHODS OF USE | AMGEN INC. (US) | 2010-04-08 | — | — | US | disclosed |
| US-20100010250-A1 | METHODS FOR PREPARING 2-METHOXYISOBUTYLISONITRILE AND TETRAKIS(2-METHOXYISOBUTYLISONITRILE)COPPER(I) TETRAFLUOROBORATE | Draximage Limited (IE) | 2010-01-14 | — | — | US | disclosed |
| EP-2099742-A1 | METHODS FOR PREPARING 2-METHOXYISOBUTYLISONITRILE AND TETRAKIS(2-METHOXYISOBUTYLISONITRILE)COPPER(I) TETRAFLUOROBORATE | Draximage Limited (IE) | 2009-09-16 | — | — | EP | disclosed |
| US-7563920-B2 | Methods for preparing 2-methoxyisobutylisonitrile and tetrakis(2-methoxyisobutylisonitrile)copper(I) tetrafluoroborate | Draximage Limited (IE) | 2009-07-21 | — | — | US | disclosed |
| WO-2008053285-A1 | METHODS FOR PREPARING 2-METHOXYISOBUTYLISONITRILE AND TETRAKIS(2-METHOXYISOBUTYLISONITRILE)COPPER(I) TETRAFLUOROBORATE | Draximage Limited (IE) | 2008-05-08 | — | — | WO | disclosed |
| US-20080102028-A1 | METHODS FOR PREPARING 2-METHOXYISOBUTYLISONITRILE AND TETRAKIS(2-METHOXYISOBUTYLISONITRILE)COPPER(I) TETRAFLUOROBORATE | DRAXIS SPECIALTY PHARMACEUTICALS INC. (CA) | 2008-05-01 | — | — | US | disclosed |
| EP-0546233-B1 | Method for synthesis and 99mTc labelling of 2-alkoxyisobutylisonitrile | INST NUCLEAR ENERGY RES (TW) | 1995-03-01 | — | — | EP | disclosed |
| US-5346995-A | Preparation of copper 2-alkoxyisobutylisonitrile complexes and 99m Tc labelling of 2-alkoxyisobutylisonitrile | INSTITUTE OF NUCLEAR ENERGY RESEARCH (TW) | 1994-09-13 | — | — | US | disclosed |
| EP-0546233-A1 | Method for synthesis and 99mTc labelling of 2-alkoxyisobutylisonitrile | INSTITUTE OF NUCLEAR ENERGY RESEARCH, CHINESE ATOMIC ENERGY COUNCIL (TW) | 1993-06-16 | — | — | EP | disclosed |
| US-5210270-A | Method for synthesis and 99m C labelling of 2-alkoxyisobutylisonitrile | INSTITUTE OF NUCLEAR ENERGY RESEARCH (TW) | 1993-05-11 | — | — | US | disclosed |